CAPN10 Alleles Are Associated with Polycystic Ovary Syndrome-Reference-Cited by-同舟云学术

CAPN10 Alleles Are Associated with Polycystic Ovary Syndrome

Published:2002-08-01 Issue:8 Volume:87 Page:3971-3976
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Gonzalez Alejandro¹,Abril Eduardo²,Roca Alfredo²,Aragón Maria José²,Figueroa Maria José²,Velarde Pilar²,Royo José Luis³,Real Luis Miguel³,Ruiz Agustín³

Affiliation:

1. Unidad Materno- Infantil, Hospital Virgen de las Montañas (A.G.), Villamartin, Cádiz, Spain

2. Centro Avanzado de Fertilidad, Unidad de Reproducción y Genética Humana, Instituto Medico Serman, Jerez de la Frontera (A.G., E.A., A.Ro., M.J.A., M.J.F., P.V.), Cádiz, Spain

3. Departamento de Genómica Estructural, Neocodex, Parque Científico y Tecnológico Isla de la Cartuja (J.L.R., L.M.R., A.Ru.), Sevilla, Spain

Abstract

Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation infertility, hyperandrogenemia, and frequently insulin resistance. This study investigated whether polymorphisms in the CAPN10 gene are related with PCOS etiology. The allelic frequencies and genotypes of CAPN10 polymorphisms UCSNP-44, 43, 19, and 63 were determined in 55 well characterized women with polycystic ovaries and 93 unrelated healthy controls using spectrofluorimetric analyses and real-time PCR. Our data indicate that CAPN10 UCSNP-44 allele is associated with PCOS in the Spanish population (P = 0.01). These results support a role of Calpain 10 gene in PCOS susceptibility in humans.

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

http://academic.oup.com/jcem/article-pdf/87/8/3971/9159490/jcem3971.pdf

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