Cyclin D1 Protein Expression Predicts Metastatic Behavior in Thyroid Papillary Microcarcinomas But Is Not Associated with Gene Amplification

Author:

Khoo Mark L. C.12,Ezzat Shereen34,Freeman Jeremy L.25,Asa Sylvia L.16

Affiliation:

1. Department of Pathology, University Health Network (M.L.C.K., S.L.A.), Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2M9

2. Department of Otolaryngology (M.L.C.K., J.L.F.), Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2M9

3. Department of Medicine (Endocrinology) (S.E.), Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2M9

4. Department of Medicine (S.E.), University of Toronto, Toronto, Ontario, Canada M5G 2M9

5. Department of Otolaryngology (J.L.F.), University of Toronto, Toronto, Ontario, Canada M5G 2M9

6. Departments of Laboratory Medicine and Pathobiology (S.L.A.), University of Toronto, Toronto, Ontario, Canada M5G 2M9

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference27 articles.

1. Occult micropapillary carcinoma associated with benign follicular thyroid disease and unrelated thyroid neoplasms;Fink;Mod Pathol,1996

2. Clinicopathologic and immunohistochemical studies of papillary thyroid microcarcinoma presenting with cervical lymphadenopathy;Sugitani;World J Surg,1998

3. Asa SL Underexpression of p27/Kip1 in metastasizing papillary microcarcinomas of the thyroid;Khoo

4. The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation;Pestell;Endocr Rev,1999

5. Molecular and immunohistochemical analysis of the bcl-1/cyclin D1 gene in laryngeal squamous cell carcinomas: correlation of protein expression with lymph node metastases and advanced clinical stage;Fracchiolla;Cancer,1997

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