PDE5 Inhibition Stimulates Tie2-Expressing Monocytes and Angiopoietin-1 Restoring Angiogenic Homeostasis in Diabetes
Author:
Affiliation:
1. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
2. Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy
Funder
Ministero dell’Istruzione, dell’Università e della Ricerca
Publisher
The Endocrine Society
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism
Link
http://academic.oup.com/jcem/article-pdf/104/7/2623/28670947/jc.2018-02525.pdf
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3. TIE2-expressing monocytes/macrophages regulate revascularization of the ischemic limb;Patel;EMBO Mol Med,2013
4. A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood “resident” monocytes, and embryonic macrophages suggests common functions and developmental relationships;Pucci;Blood,2009
5. Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages;He;Blood,2012
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