Pasireotide Responsiveness in Acromegaly Is Mainly Driven by Somatostatin Receptor Subtype 2 Expression

Author:

Muhammad Ammar1ORCID,Coopmans Eva C1,Gatto Federico2ORCID,Franck Sanne E1,Janssen Joseph A M J L1ORCID,van der Lely Aart Jan1,Hofland Leo J1,Neggers Sebastian J C M M1

Affiliation:

1. Department of Medicine, Endocrinology Section, Pituitary Center Rotterdam, Erasmus University Medical Center, Rotterdam, Netherlands

2. Endocrinology Unit, Department of Internal Medicine and Medical Specialties, Ospedale Policlinico San Martino, Genova, Italy

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference36 articles.

1. Medical progress: Acromegaly;Melmed;N Engl J Med,2006

2. A meta-analysis of the effect of lowering serum levels of GH and IGF-I on mortality in acromegaly;Holdaway,2008

3. Quantitative analysis of somatostatin receptor subtype (SSTR1-5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas;Taboada,2007

4. Selective loss of somatostatin receptor 2 in octreotide-resistant growth hormone-secreting adenomas;Plöckinger;J Clin Endocrinol Metab,2008

5. Immunoreactivity score using an anti-sst2A receptor monoclonal antibody strongly predicts the biochemical response to adjuvant treatment with somatostatin analogs in acromegaly;Gatto;J Clin Endocrinol Metab,2013

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