Effects of Toremifene, a Selective Estrogen Receptor Modulator, on Spontaneous and Stimulated GH Secretion, IGF-I, and IGF-Binding Proteins in Healthy Elderly Subjects

Author:

Roelfsema Ferdinand1,Yang Rebecca J2,Takahashi Paul Y3,Erickson Dana4,Bowers Cyril Y5,Veldhuis Johannes D2

Affiliation:

1. Department of Internal Medicine, Section of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands

2. Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota

3. Department of Primary Care Internal Medicine, Mayo Clinic, Rochester, Minnesota

4. Department of Endocrinology, Mayo Clinic, Rochester, Minnesota

5. Department of Internal Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana

Funder

National Institutes of Health

National Center for Advancing Translational Sciences

Publisher

The Endocrine Society

Subject

Endocrinology, Diabetes and Metabolism

Reference40 articles.

1. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human;Giustina;Endocr Rev,1998

2. Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin’s dose-dependent inhibition of fasting growth hormone secretion;Bray;J Clin Endocrinol Metab,2001

3. Short-term estradiol supplementation augments growth hormone (GH) secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women;Anderson;J Clin Endocrinol Metab,2001

4. Estradiol supplementation in postmenopausal women doubles rebound-like release of growth hormone (GH) triggered by sequential infusion and withdrawal of somatostatin: evidence that estrogen facilitates endogenous GH-releasing hormone drive;Veldhuis;J Clin Endocrinol Metab,2004

5. Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men;Gentili;J Clin Endocrinol Metab,2002

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