Somatic VHL Mutation in a Patient With MEN1-Associated Metastatic Pancreatic Neuroendocrine Tumor Responding to Sunitinib Treatment: A Case Report

Author:

Shell Jasmine1,Patel Dhaval1,Powers Astin2,Quezado Martha2,Killian Keith3,Meltzer Paul3,Zhu Jack3,Gaitanidis Apostolos1,Karzai Fatima4,Neychev Vladimir1,Green Patience1,Kebebew Electron15

Affiliation:

1. Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

2. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

3. Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

4. Genitourinary Malignancies Branch, Medical Oncology Service, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

5. Department of Surgery, The George Washington University School of Medicine and Health Sciences, Washington, DC 20052

Publisher

The Endocrine Society

Subject

Endocrinology, Diabetes and Metabolism

Reference22 articles.

1. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors;Jiao;Science,2011

2. Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1);Thakker;J Clin Endocrinol Metab,2012

3. Hereditary pancreatic endocrine tumours;Alexakis;Pancreatology,2004

4. Differential genetic alterations in von Hippel-Lindau syndrome-associated and sporadic pheochromocytomas;Bender;J Clin Endocrinol Metab,2000

5. Endocrine manifestations of von Hippel-Lindau disease;Cassol;Arch Pathol Lab Med,2015

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