Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D

Author:

Roels Sarah1ORCID,Costa Olivier R12ORCID,Tersey Sarah A3ORCID,Stangé Geert1,De Smet Dieter4,Balti Eric V1ORCID,Gillard Pieter5ORCID,Keymeulen Bart12,Ling Zhidong12,Pipeleers Daniel G1ORCID,Gorus Frans K1,Mirmira Raghavendra G36,Martens Geert A14ORCID

Affiliation:

1. Diabetes Research Center, Brussels Free University, Brussels, Belgium

2. Department of Clinical Biology, University Hospital Brussels (UZ Brussel), Brussels, Belgium

3. Department of Pediatrics, IU Center for Diabetes and Metabolic Disease, Indiana University School of Medicine, Indianapolis, Indiana

4. Department of Laboratory Medicine, AZ Delta, Roeselare, Belgium

5. Department of Endocrinology, University Hospitals Leuven – Katholieke Universiteit Leuven, Leuven, Belgium

6. Departments of Biochemistry and Molecular Biology, Medicine, and Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana

Funder

Fonds Wetenschappelijk Onderzoek

Agentschap voor Innovatie door Wetenschap en Technologie

Wetenschappelijk Fonds Willy Gepts, UZ Brussel

European Foundation for the Study of Diabetes

Vrije Universiteit Brussel

JDRF

National Institutes of Health

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference29 articles.

1. Human pancreatic islet preparations release HMGB1:(ir)relevance for graft engraftment;Nano;Cell Transplant,2013

2. Elevation of high-mobility group box 1 after clinical autologous islet transplantation and its inverse correlation with outcomes;Itoh;Cell Transplant,2014

3. Plasma GAD65, a marker for early β-cell loss after intraportal islet cell transplantation in diabetic patients;Ling;J Clin Endocrinol Metab,2015

4. Detection of insulin mRNA in the peripheral blood after human islet transplantation predicts deterioration of metabolic control;Berney;Am J Transplant,2006

5. Detection of β cell death in diabetes using differentially methylated circulating DNA;Akirav;Proc Natl Acad Sci USA,2011

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