Transfer and Metabolism of Cortisol by the Isolated Perfused Human Placenta

Author:

Stirrat Laura I1,Sengers Bram G23,Norman Jane E1,Homer Natalie Z M45,Andrew Ruth45,Lewis Rohan M36,Reynolds Rebecca M15

Affiliation:

1. Tommy’s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom

2. Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom

3. Institute for Life Sciences, University of Southampton, Southampton, United Kingdom

4. Mass Spectrometry Core, Edinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, United Kingdom

5. University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom

6. Faculty of Medicine, University of Southampton, Southampton, United Kingdom

Funder

Medical Research Council

British Heart Foundation

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference37 articles.

1. Type 2 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: its relationship to birth weight and putative role in fetal adrenal steroidogenesis;Stewart;J Clin Endocrinol Metab,1995

2. Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis--2012 Curt Richter Award Winner;Reynolds;Psychoneuroendocrinology,2013

3. A longitudinal study of plasma and urinary cortisol in pregnancy and postpartum;Jung;J Clin Endocrinol Metab,2011

4. The metabolic clearance rate, blood production, interconversion and transplacental passage of cortisol and cortisone in pregnancy near term;Beitins;Pediatr Res,1973

5. Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform;Brown;Endocrinology,1993

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