Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myenteric Neuronal Mechanisms in Humans

Author:

Halim Md Abdul1,Degerblad Marie2,Sundbom Magnus3,Karlbom Urban3,Holst Jens Juul4,Webb Dominic-Luc1,Hellström Per M1

Affiliation:

1. Department of Medical Sciences, Gastroenterology Unit, Uppsala University, Uppsala, Sweden

2. Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden

3. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

4. NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

Funder

Swedish Research Council

Karolinska Institutet

Bengt Ihre’s Foundation

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference50 articles.

1. Backwards and forwards with the migrating complex;Wingate;Dig Dis Sci,1981

2. Glucagon-like peptide-1 7-36: a physiological incretin in man;Kreymann;Lancet,1987

3. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans;Schjoldager;Dig Dis Sci,1989

4. Differential effects of subcutaneous GLP-1 on gastric emptying, antroduodenal motility, and pancreatic function in men;Schirra;Proc Assoc Am Physicians,1997

5. Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed motility inhibited via nitric oxide independently of insulin and somatostatin;Tolessa;J Clin Invest,1998

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