Leptin Within the Subphysiological to Physiological Range Dose Dependently Improves Male Reproductive Function in an Obesity Mouse Model

Author:

Hoffmann Annett1,Manjowk Gloria-Maria1,Wagner Isabel Viola23,Klöting Nora2,Ebert Thomas12,Jessnitzer Beate13,Lössner Ulrike12,Stukenborg Jan-Bernd,Blüher Matthias1,Stumvoll Michael1,Söder Olle3,Svechnikov Konstantin3,Fasshauer Mathias12,Kralisch Susan12

Affiliation:

1. Department of Endocrinology and Nephrology (A.H., G.-M.M., T.E., B.J., U.L., M.B., M.S., M.F., S.K.), , Leipzig University Medical Center, 04103 Leipzig, Germany

2. University of Leipzig, and Integrated Research and Treatment Center (IFB) Adiposity Diseases (I.V.W., N.K., T.E., U.L., M.F., S.K.), Leipzig University Medical Center, 04103 Leipzig, Germany;

3. Department of Women's and Children's Health, Pediatric Endocrinology Unit (I.V.W., J.-B.S., O.S., K.S.), Karolinska Institutet and University Hospital, 17176 Stockholm, Sweden

Publisher

The Endocrine Society

Subject

Endocrinology

Reference43 articles.

1. A potential decline in life expectancy in the United States in the 21st century;Olshansky;N Engl J Med,2005

2. Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels;Isidori;J Clin Endocrinol Metab,1999

3. The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review;Michalakis;Metabolism,2013

4. Diet-induced obesity in rats leads to a decrease in sperm motility;Fernandez;Reprod Biol Endocrinol,2011

5. SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity;Palmer;Reprod Fertil Dev,2011

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