Ligand-Controlled Interaction of Histone Acetyltransferase Binding to ORC-1 (HBO1) with the N-Terminal Transactivating Domain of Progesterone Receptor Induces Steroid Receptor Coactivator 1-Dependent Coactivation of Transcription

Author:

Georgiakaki Maria1,Chabbert-Buffet Nathalie2,Dasen Boris1,Meduri Geri1,Wenk Sandra1,Rajhi Leila1,Amazit Larbi3,Chauchereau Anne4,Burger Curt W.5,Blok Leen J.5,Milgrom Edwin6,Lombès Marc1,Guiochon-Mantel Anne1,Loosfelt Hugues1

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 693 (A.G.-M., B.D., G.M., H.L., L.R., M.G., M.L., S.W.), Récepteurs Stéroïdiens, Physiopathologie Endocrinienne et Métabolique, Faculté de Médecine Paris-Sud, 94276 Le Kremlin-Bicêtre Cedex, France;

2. Unité de Médecine Vasculaire (N.C.-B.), Hôpital Tenon Assistance Publique-Hôpitaux de Paris, 75020 Paris, France;

3. Department of Molecular and Cellular Biology (L.A.), Baylor College of Medicine, Houston, Texas 77030;

4. Centre National de la Recherche Scientifique (CNRS), Unité Propre de Recherche 9079 (A.C.), Institut Andre Lwoff, 94800 Villejuif, France;

5. Department of Reproduction and Development and Obstetrics and Gynaecology (L.J.B., C.W.B.), Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands

6. Biochimie Hormonale (E.M.), Hôpital de Bicêtre, 94275 Le Kremlin-Bicêtre, France;

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference71 articles.

1. Transcription factors 3: nuclear receptors.;Gronemeyer;Protein Profile,1995

2. A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms.;Meyer;J Biol Chem,1992

3. A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform.;Sartorius;Mol Endocrinol,1994

4. Mapping the unique activation function 3 in the progesterone B-receptor upstream segment. Two LXXLL motifs and a tryptophan residue are required for activity.;Tung;J Biol Chem,2001

5. The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.;Giangrande;Mol Cell Biol,2000

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