SOM230 Inhibits Insulin-Like Growth Factor-I Action in Mammary Gland Development by Pituitary Independent Mechanism: Mediated through Somatostatin Subtype Receptor 3?

Author:

Ruan Weifeng12,Fahlbusch Fabian12,Clemmons David R.3,Monaco Marie E.4,Walden Paul D.56,Silva Antonio P.7,Schmid Herbert A.7,Kleinberg David L.12

Affiliation:

1. Neuroendocrine Unit (W.R., F.F., D.L.K.), New York, New York 10016;

2. Departments of Medicine (W.R., F.F., D.L.K.), New York, New York 10016;

3. Division of Endocrinology (D.R.C.), University of North Carolina, Chapel Hill, North Carolina 27599;

4. Physiology (M.E.M.), New York, New York 10016;

5. Urology (P.D.W.), New York, New York 10016;

6. Biochemistry (P.D.W.), New York University School of Medicine, New York, New York 10016;

7. Novartis Institutes for Biomedical Research (A.P.S., H.A.S.), Department of Oncology, CH-4057 Basel, Switzerland

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference42 articles.

1. Anterior pituitary.;Melmed;Williams textbook of endocrinology.,2003

2. Safety and efficacy of long term octreotide therapy of acromegaly: results of a multicenter trial in 103 patients—a clinical research center study.;Newman;J Clin Endocrinol Metab,1995

3. SOM230: a new somatostatin peptidomimetic with potent inhibitory effects on the growth hormone/insulin-like growth factor-I axis in rats, primates, and dogs.;Weckbecker;Endocrinology,2002

4. Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis.;Murray;J Clin Invest,2004

5. Intact and aminoterminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development.;Ruan;Proc Natl Acad Sci USA,1992

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