Morphological and Immunohistochemical Differences between Gonadal Maturation Delay and Early Germ Cell Neoplasia in Patients with Undervirilization Syndromes

Author:

Cools Martine1,van Aerde Koen1,Kersemaekers Anne-Marie1,Boter Marjan1,Drop Stenvert L. S.2,Wolffenbuttel Katja P.3,Steyerberg Ewout W.4,Oosterhuis J. Wolter1,Looijenga Leendert H. J.1

Affiliation:

1. Department of Pathology (M.C., K.v.A., A.-M.K., M.B., J.W.O., L.H.J.L.), Erasmus MC, University Medical Center Rotterdam, Daniel den Hoed, Josephine Nefkens Institute, 3000 DR Rotterdam, The Netherlands;

2. Departments of Pediatric Endocrinology (S.L.S.D.), 3000 CB Sophia, The Netherlands;

3. Pediatric Urology (K.P.W.), Erasmus MC, University Medical Center Rotterdam, 3000 CB Sophia, The Netherlands;

4. Center for Clinical Decision Sciences (E.W.S.), Department of Public Health, Erasmus MC, University Medical Center, 3000 DR Rotterdam, The Netherlands

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference39 articles.

1. Disorders of sex differentiation;Grumbach;In: Polonsky KM, ed. Williams textbook of endocrinology. Philadelphia: W.B. Saunders;,2003

2. Abnormal sexual differentiation and neoplasia.;Verp;Cancer Genet Cytogenet,1987

3. Testicular feminization syndrome and associated gonadal tumors in Denmark.;Bangsboll;Acta Obstet Gynecol Scand,1992

4. Molecular biology and function of the androgen receptor in genital development.;Wiener;J Urol,1997

5. The age of occurrence of gonadal tumors in intersex patients with a Y chromosome.;Manuel;Am J Obstet Gynecol,1976

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