Treatment with Flutamide, Metformin, and Their Combination Added to a Hypocaloric Diet in Overweight-Obese Women with Polycystic Ovary Syndrome: A Randomized, 12-Month, Placebo-Controlled Study

Author:

Gambineri Alessandra1,Patton Laura1,Vaccina Antonella1,Cacciari Mauro1,Morselli-Labate Antonio Maria1,Cavazza Carla1,Pagotto Uberto1,Pasquali Renato1

Affiliation:

1. Division of Endocrinology, Department of Internal Medicine, and Center for Applied Biomedical Research, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference45 articles.

1. Polycystic ovary syndrome;Franks;N Engl J Med,1995

2. Clinical and hormonal characteristics of obese amenorrheic hyperandrogenic women before and after weight loss;Pasquali;J Clin Endocrinol Metab,1989

3. 17α-Hydroxyprogesterone responses to leuprolide and serum androgens in obese women with and without polycystic ovary syndrome after dietary weight loss;Jakubowicz;J Clin Endocrinol Metab,1997

4. Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17α activity and serum androgens;Nestler;J Clin Endocrinol Metab,1997

5. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome;Nestler;N Engl J Med,1998

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