Membrane Restraint of Estrogen Receptor α Enhances Estrogen-Dependent Nuclear Localization and Genomic Function

Author:

Xu Yun12,Traystman Richard J.1,Hurn Patricia D.1,Wang Michael M.1

Affiliation:

1. Departments of Anesthesiology/Critical Care Medicine (Y.X., R.J.T., P.D.H., M.M.W.) and Neurology, Johns Hopkins University, Ross 364, Baltimore, Maryland 21287

2. Department of Neurology (Y.X.), The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, People’s Republic of China

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference44 articles.

1. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERα and ERβ expressed in Chinese hamster ovary cells.;Razandi;Mol Endocrinol,1999

2. Estrogen receptor (ER)α and ERβ exhibit unique pharmacologic properties when coupled to activation of the mitogen-activated protein kinase pathway.;Wade;Endocrinology,2001

3. Cellular functions of plasma membrane estrogen receptors.;Levin;Steroids,2002

4. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells.;Haynes;Circ Res,2000

5. Membrane association of estrogen receptor α mediates estrogen effect on MAPK activation.;Zhang;Biochem Biophys Res Commun,2002

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