1. Department of Primary Care and Public Health (C.L.M., C.D.P., C.J.C.), Cardiff CF14 4UJ, United Kingdom
2. Department of Medicine (M.E.), University Hospital of Wales, Llandough, Cardiff CF64 2XX, United Kingdom
3. Division of Clinical and Experimental Medicine (A.H.B.), University of Birmingham, and Biomedical Research Unit, Heart of England National Health Service Trust, Birmingham B9 5ST, United Kingdom; University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
4. School of Medicine, Cardiff University, The Pharma Research Centre, and Department of Global Epidemiology (S.J.-J.), Pharmatelligence, Cardiff MediCentre, Cardiff CF14 4UJ, United Kingdom