Metabolic Signature Shift in Type 2 Diabetes Mellitus Revealed by Mass Spectrometry-based Metabolomics

Author:

Xu Fengguo1,Tavintharan Subramaniam2,Sum Chee Fang2,Woon Kaing3,Lim Su Chi2,Ong Choon Nam4

Affiliation:

1. School of Public Health (F.X., C.N.O.), National University of Singapore, Singapore 117597

2. Diabetes Centre (S.T., C.F.S., S.C.L.), Khoo Teck Puat Hospital, Singapore

3. Clinical Research Unit (K.W.), Khoo Teck Puat Hospital, Singapore 768828

4. National University of Singapore Environmental Research Institute (C.N.O.), Singapore 117597

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference20 articles.

1. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance;Tuomilehto;N Engl J Med,2001

2. Multiorigination of chromatographic peaks in derivatized GC/MS metabolomics: a confounder that influences metabolic pathway interpretation;Xu;J Proteome Res,2009

3. Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men;Tai;Diabetologia,2010

4. Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women;Redman;J Clin Endocrinol Metab,2011

5. Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes;Mitsutake;J Biol Chem,2011

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