Acil Serviste Prokalsitonin Düzeyi ile Kısa Dönem Mortalite Arasındaki İlişki

Author:

CEHRELİ Onur Barıs1ORCID,BAYRAM Başak2ORCID,GÜRSOYLU Duygu3ORCID,COLAK Nese4ORCID

Affiliation:

1. Brüderkrankenhaus St. Josef Paderborn Hospital, Department of Anesthesiology

2. Dokuz Eylul University, School of Medicine,

3. Golbasi Sehit Ahmet Ozsoy State Hospital

4. DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ

Abstract

Aim: Procalcitonin (PCT) is a biomarker for infection, which has grown in popularity in recent years. In our study, we investigated whether there was a relationship between procalcitonin levels and seven-day mortality in all patients whose procalcitonin levels were measured in the emergency department (ED). Material and Methods: In this single-center, cross-sectional, analytic, retrospective study, the patients whose PCT levels were measured in Dokuz Eylül University Hospital adult emergency department between 01.01.2016 and 31.03.2016 were included. PCT level and other parameters were evaluated in the survived and non- survived groups, Results: We analyzed 499 patients whose PCT levels were measured. The median age was 74 (IQR: 63-82) years, and 54% were male. Of the 499 patients, 6 (1.2%) had a low procalcitonin level (median 0.03: IQR 0.02-0.04), 407 (81.6%) had an intermediate procalcitonin level (median 0.26; IQR 0.16-0.54) and 86 (17.2%) had a high procalcitonin level (median 5.54; IQR 3.20-15.31). When the PCT level-high group was compared with the other groups; systolic blood pressure (SBP), diastolic blood pressure (DBP), platelet count, pCO2 were lower and pulse rate, WBC, lactate, base excess values were higher. It was found that 249 (49.9%) of the patients were discharged from the ED, 112 (22.4%) were hospitalized, 66 (13.2%) were hospitalized in the intensive care unit, and 72 (14.4%) died. The PCT level was higher in the non-survivor group than in the survivor group (0.29 ngr/mL vs 1.07 ngr/mL, p

Publisher

Emergency Medicine Association of Turkey

Reference15 articles.

1. Maruna P, Nedelníková K, Gürlich R. Physiology and genetics of procalcitonin. Physiol Res. 2000;49 Suppl 1:S57-S61.

2. Becker KL, Nylén ES, White JC, et al. Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab. 2004 Apr;89(4):1512-25.

3. Cleland DA, Eranki AP. Procalcitonin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; September 16, 2019.

4. So-Ngern A, Leelasupasri S, Chulavatnatol S, et al. Prognostic Value of Serum Procalcitonin level for the Diagnosis of Bacterial Infections in Critically-ill Patients. Infect Chemother. 2019 Sep;51(3):263-273

5. Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-1247.

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