Ethylene oxide: methodological approaches to the determination of residues in food products (literature review)

Author:

Lukashkin Nikita A.1ORCID,Araslanov Ilgiz N.2ORCID

Affiliation:

1. Center of Hygiene and Epidemiology in the Moscow region

2. Russian Register of Potentially Hazardous Chemical and Biological Substances — Branch of Federal Scientific Center of Hygiene named after F.F. Erisman

Abstract

Introduction. Ethylene oxide is a prohibited fumigant in the Russian Federation and the states of the European Union (EU), however, the substance is used in a number of other countries to disinfect food before they are sold, so there is a risk of such products entering the Russian market, which can lead to negative consequences for public health. The residues of the fumigant in consumed products can cause neurological disorders and the development of cancer in humans. In addition, the presence of 2-chloroethanol in foodstuffs, the main transformation product of ethylene oxide, which is formed during the interaction of the fumigant with the matrix, is of concern. Material and methods. The analysis of domestic and foreign databases and regulatory legal acts on the regulation of the dangers of ethylene oxide and 2-chloroethanol was carried out. Results. The toxicological characterization of ethylene oxide and 2-chloroethanol shows the need to establish acceptable levels of contaminants in food, and, as a result, to create a simple and effective analytical control method. Limitations.The study is limited to a review of open literature sources in describing the toxicological characterization and methods of analysis of ethylene oxide in food products. Conclusion. The analysis of open literature sources has shown the need for scientific substantiation of hygienic standards and the development of a method for controlling the content of ethylene oxide and 2-chloroethanol in food products.

Publisher

Federal Scientific Center for Hygiene F.F.Erisman

Reference53 articles.

1. Rudakov O.B. Ethylene oxide. In: The Great Russian Encyclopedia. Vol. 35. Мoscow: 2017: 488. (in Russian).

2. EURL-SRM-Analytical Observation Report, Analysis of Ethylene Oxide and its metabolite 2-Chloroethanol by the QuOil or the QuEChERS method and GC–MS/MS (December 2020).

3. Mendes G.C., Brandao T.R., Silva C.L. Ethylene oxide sterilization of medical devices: A review. Am. J. Infect. Control. 2007; 35: 574–81.

4. Rutala W.A., Weber D.J. Guideline for Disinfection and Sterilization in Healthcare Facilities. United States Centers for Disease Control and Prevention: Atlanta, GA, USA, 2008.

5. Fowles J., Mitchell J., McGrath H. Assessment of cancer risk from ethylene oxide residues in spices imported into New Zealand. Food Chem Toxicol. 2001; 39: 1055–62.

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