Affiliation:
1. Research Institute for Complex Problems of Hygiene and Occupational Diseases; Novokuznetsk State Institute for Further Training of Physicians — Branch Campus of the “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation
2. Research Institute for Complex Problems of Hygiene and Occupational Diseases
Abstract
Introduction. Clinical studies have shown the development of a complex of non-specific changes in internal organs due to chronic fluoride intoxication. The accumulation of fluorine in the body initiates free radical oxidation, promotes the development of pathological processes in the heart against the background of an imbalance between pro- and antioxidants, and vascular endothelial dysfunction. Pathological activation of intima cells leads to unbalanced production of damaging factors, changes in the hemostasis system, and entails morphological and functional disorders of organs.
Materials and methods. The experiments were carried out on one hundred twenty white male rats. A morphological study of the heart, blood vessels was performed out at 1, 3, 6, 9 and 12 weeks of chronic fluoride intoxication.
Results. The 1st-3rd weeks of the experiment are characterized by the preservation of the morphological structure of the cardiac muscle against the background of the previously shown a compensatory activation of the components of the redox-signalling system, which provided a decrease in the intensity of free radical processes. With an increase in the duration of exposure to sodium fluoride (6–9 weeks) these mechanisms failure was noted, which was manifested by the development of degenerative changes in the myocardium, progressing up to the 12th week of the experiment. The described changes correlated with the development of endotheliosis, degenerative and fibroplastic processes, circulatory disorders in the vessels of the heart and other organs.
Limitations. Histological findings are descriptive.
Conclusion. The results obtained are of practical importance for the elaboration of effective methods for timely organ-protective prevention and correction of pathomorphological disorders, depending on the organ-specific features and duration of fluoride intoxication.
Publisher
Federal Scientific Center for Hygiene F.F.Erisman
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Pollution,General Medicine
Reference32 articles.
1. Roslaya H.A., Likhacheva E.I., Oranskiy I.E., Odinokaya V.A., Plotko E.G., Zhovtyak E.P., et al. Clinical and pathogenetic aspects of the chronic occupational intoxication with fluorine compounds in modern reality. Meditsina truda i promyshlennaya ekologiya. 2012; (11): 17–21. https://elibrary.ru/pihqlh (in Russian)
2. Clinical recommendations. Occupational intoxication with fluorine compounds (project). Meditsina truda i promyshlennaya ekologiya. 2018; (1): 48–63. https://elibrary.ru/ytbqig (in Russian)
3. Chouhan S., Lomash V., Flora S.J.S. Fluoride-induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats. J. Appl. Toxicol. 2010; 30(1): 63–73. https://doi.org/10.1002/jat.1474
4. Cicek E., Aydin G., Akdogan M., Okutan H. Effects of chronic ingestion of sodium fluoride on myocardium in a second generation of rats. Hum. Exp. Toxicol. 2005; 24(2): 79–87. https://doi.org/10.1191/0960327105ht505oa
5. Miao K., Zhang L., Yang S., Qian W., Zhang Z. Intervention of selenium on apoptosis and Fas/FasL expressions in the liver of fluoride-exposed rats. Environ. Toxicol. Pharmacol. 2013; 36(3): 913–20. https://doi.org/10.1016/j.etap.2013.08.003