Affiliation:
1. Research Institute for Complex Problems of Hygiene and Occupational Diseases
2. Novokuznetsk State Institute for Further Training of Physicians – Branch Campus of the “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation
3. Novokuetsk Branch of the Kuzbass Clinical Oncological Dispensary named after M.S. Rappoport
Abstract
Introduction. Missed pregnancy, as a rule, is caused by a combination of several factors. Exogenous factors can have a teratogenic effect, leading to the occurrence of mutations of varying severity. In such case at the early stages of embryogenesis, serious disturbances occur, leading to a halt in the pregnancy development. The system of their biotransformation is responsible for the elimination of xenobiotics from the body, the inadequate functioning of which increases the activity of mutagenesis, which may raise the risk of breast cancer.
Materials and methods. One hundred thirty four women were examined. The first group included 63 women, 28 of them were diagnosed with fetal egg death in primigravida young women, in 35 women the first pregnancy ended with physiological childbirth. The second group included 71 woman, 33 of them were diagnosed with a malignant breast neoplasm, 38 had no suspicion of breast cancer (BC) according to the results of mammography. Polymorphisms of the CYP1A2*1F gene of the xenobiotic biotransformation system in these groups were determined by polymerase chain reaction.
Results. In the group of women with a missed first pregnancy, a statistically reliable association of a high risk of the fetal egg death with the A/A CYP1A2*1F genotype and resistance to this pathology in the case of the C/A CYP1A2*1F polymorphism was revealed. In the group of BC women, the association of a high risk of developing a malignant neoplasm with the A/A CYP1A2*1F genotype and resistance to the development of the disease in the presence of C/A CYP1A2*1F polymorphism was shown.
Limitations. The study was limited by the number of samples, there is no data on polymorphisms of the BRCA-1, BRCA-2 genes.
Conclusion. The results obtained will allow not only adjusting the tactics of pregnancy management in women with a high risk of the fetal egg death or the selection of pharmacological drugs in the treatment of BC under the conditions of serious environmental stress, but also developing preventive measures to reduce the risk of these pathologies.
Publisher
Federal Scientific Center for Hygiene F.F.Erisman
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Pollution,General Medicine
Reference29 articles.
1. Federal State Statistics Service; 2023. Available at: https://rosstat.gov.ru/ (in Russian)
2. Shkurat T.P., Mashkina E.V., Kovalenko K.A., Volosovtsova G.I. Method of predicting high risk of reproductive loss in first trimester of pregnancy. Patent RF No. 2611358; 2017. (in Russian)
3. Radzinskiy V.E., ed. Non-Developing Pregnancy [Nerazvivayushchayasya beremennost’]. Moscow: GEOTAR-Media; 2019. (in Russian)
4. Dobrokhotova Yu.E., Mandrykina Zh.A., Narimanova M.R. Missed abortion: Reasons and possibilities for rehabilitation. Rossiyskiy vestnik akushera-ginekologa. 2016; 16(4): 85–90. https://doi.org/10.17116/rosakush201616485-90 https://elibrary.ru/wjhfrt (in Russian)
5. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer. 2010; 127(12): 2893–917. https://doi.org/10.1002/ijc.25516