Evaluation of the cytotoxic combined effect of selenium and copper oxide nanoparticles in an acute experiment on rats-Reference-Cited by-同舟云学术

Evaluation of the cytotoxic combined effect of selenium and copper oxide nanoparticles in an acute experiment on rats

Published:2023-01-12 Issue:12 Volume:101 Page:1588-1595
ISSN:2412-0650
Container-title:Hygiene and sanitation
language:
Short-container-title:

Author:

Ryabova Yuliya V.¹^ORCID,Tazhigulova Anastasia V.¹^ORCID

Affiliation:

1. Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

Abstract

Introduction. In the scientific literature known to us, there are no experimental data on the combined human health effect of nanoparticles of selenium and copper oxides, the exposure to which is feasible in metallurgy. Materials and methods. The cytotoxic effect was modelled on outbred female rats by a single intratracheal instillation of suspended nanoparticles of selenium and copper oxides at a concentration of 0.25 mg/ml. Cytological and biochemical parameters of the bronchoalveolar lavage fluid were evaluated 24 hours after the administration of the suspension. Results. The response of the lower airways to the combined exposure to SeO and CuO nanoparticles was more pronounced than that to the exposure to either of them, thus indicating its higher cytotoxicity as judged by cytological and biochemical parameters of the bronchoalveolar lavage fluid. The combined cytotoxic effect of SeO and CuO nanoparticles was characterized by typological diversity. According to the overwhelming number of the parameters studied, the additive nature of the combined effect of high exposure doses of SeO and CuO nanoparticles was demonstrated. Limitations. The research was limited to the study of the main indicators of cytotoxic effects. Conclusion. To avoid underestimation of the cumulative health risk for workers in the chemical and slime shops of copper smelters, it is important to take into consideration the additive nature of the combined effect of toxicants under study.

Publisher

Federal Scientific Center for Hygiene F.F.Erisman

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Pollution,General Medicine

Reference28 articles.

1. Naboychenko C.S., ed. Selenium and Tellurium Production at Uralelectromed OJSC [Proizvodstvo selena i tellura na OAO «Uralelektromed’»: uchebnoe posobie]. Ekaterinburg; 2015. (in Russian)

2. Lyapishchev Yu.B. Up-to-date processing of electrolytic copper refinery slimes. Zapiski Gornogo instituta. 2006; (2): 245–7. (in Russian)

3. Madar’ I.I. Hydrometallurgical extraction of selenium from products of extraction processing of washing acid of copper production: Diss. St. Petersburg; 2015. (in Russian)

4. Gurvich V.B., Katsnel’son B.A., Ruzakov V.O., Privalova L.I., Bushueva T.V. Biochemical effects in workers exposed to copper refinery nanoparticle-containing aerosols. In: Proceedings of the International Conference «Topics of Current Hygienic Importance in Nanotoxicology: Theoretical Premises, Hazards Identification and Ways of Their Attenuation» [Aktual’nye gigienicheskie aspekty nanotoksikologii: teoreticheskie osnovy, identifikatsiya opasnosti dlya zdorov’ya i puti ee snizheniya: Materialy mezhdunarodnoy konferentsii]. Yekaterinburg; 2016: 21–3. (in Russian)

5. Privalova L.I., Katsnel’son B.A., Loginova N.V., Gurvich V.B., Shur V.Ya., Beykin Ya.B., et al. Cytological and biochemical characteristics of bronchoalveolar lavage fluid in rats after intratracheal instillation of copper oxide nano-scale particles. Toksikologicheskiy vestnik. 2014; (5): 8–15. (in Russian)