Affiliation:
1. Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Abstract
Introduction. The study of sensitization under conditions of aerogenic exposure to aluminum is relevant for preventing the formation of the risk of disorders of the immunological health in the child population.
Materials and methods. Preschool three hundred fifty three children living in Eastern Siberia were examined. Observation group included 199 children living in the zone exposed to emissions from non-ferrous metallurgy enterprises, comparison group – 154 children living in a “conditionally clean” area. In the observation area, the average daily dose of aerogenic exposure to aluminum was 0.292 ∙ 10–3 mg/(kg ∙ day), in the comparison area – 0.0376 ∙ 10–3mg/(kg ∙ day). The work used sanitary-hygienic, chemical-analytical, enzyme-linked immunosorbent and allergosorbent research methods.
Results. In children living under conditions of aluminum exposure, a twofold excess of aluminum content was identified in biological environments relative to the comparison group (p = 0.001), hyperproduction of IgG to aluminum, CD19+ and CD3+CD8+ lymphocytes (1.6 times), and NKT lymphocytes
(2 times) and CD11a+ lymphocytes 1.4 times (p=0.001) was noted, which reflects an imbalance of immunoregulation and the formation of autoallergy.
A significant relationship was established between hyperproduction of total IgE and IgG to aluminum (OR=2.29–5.98; 95% CI 1.76–9.52), (RR=1.93–2.66;
95% CI: 1.41–3.54)
Limitations of the study. Limited sample size.
Conclusion. As markers of allergy and imbalance of immunoregulation in children under conditions of aerogenic exposure to aluminum and with its increased content in biological media, it is necessary to recommend IgG to aluminum as a marker of sensitivity, as well as CD11a+, reflecting the likelihood of developing a risk of developing immunological disadaptation and autosensitization (OR = 2.29–5.98), (RR=1.93–2.66).
Publisher
Federal Scientific Center for Hygiene F.F.Erisman
Reference28 articles.
1. State report «On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2022». Moscow; 2023. (in Russian)
2. Efimova N.V., Donskikh I.V., Zarodnyuk T.S., Gornov A.Yu. Assessing and forecasting morbidity of adolescents living in area influenced by aluminium production. Meditsina truda i promyshlennaya ekologiya. 2014; 54(4): 44–9. https://elibrary.ru/scevlx (in Russian)
3. Ustinova O.Yu., Valina S.L., Shtina I.E., Kobyakova O.A., Makarova V.G. Features of children’s morbidity living in area of influence enterprises for alumina production. Zdorov’e naseleniya i sreda obitaniya – ZNiSO. 2019; (1): 19–23. https://doi.org/10.35627/2219-5238/2019-310-1-18-23 https://elibrary.ru/fpuhjt (in Russian)
4. Skupnevskii S.V., Ivanov D.V. The effect of aluminum and its compounds on the functions of human organs and tissues (review article). Vestnik novykh meditsinskikh tekhnologii. Elektronnoe izdanie. 2023; 17(1): 110–24. https://doi.org/10.24412/2075-4094-2023-1-3-7 https://elibrary.ru/vgrxrm (in Russian)
5. Renke G., Almeida V.B.P., Souza E.A., Lessa S., Teixeira R.L., Rocha L., et al. Clinical outcomes of the deleterious effects of aluminum on neuro-cognition, inflammation, and health: A review. Nutrients. 2023; 5(9): 2221. https://doi.org/10.3390/nu15092221