Comparative assessment of the relationship between anthropometric and ultrasound characteristics of adipose tissue, blood lipid profile, and predictive risk of cardiovascular events in young women

Abstract

The problem of assessing the impact of disorders of lipid metabolism on cardiovascular risk remains relevant. Purpose of the study: to study the relationship between the thickness of abdominal adipose tissue and the parameters of the blood lipid profile and cardiovascular risk in young women. Materials and methods. Two hundred four young women (36.4 ± 5.4 years) were examined. Body mass index (BMI), waist circumference (WC), as well as ultrasonic criteria for adipose tissue thickness (subcutaneous and preperitoneal adipose tissue thickness, preperitoneal circumference), lipid spectrum parameters were assessed, and cardiovascular risk was calculated. Results. All criteria for assessing adipose tissue demonstrated a relationship with lipid metabolism parameters. The coefficient of determination for bonds with triglycerides ranged from 0.116 (for the thickness of preperitoneal adipose tissue) to 0.207 (for OT); for links with HDL cholesterol — from 0.030 (for BMI) to 0.052 (for OT); for links with non-HDL cholesterol — from 0.057 (for the thickness of preperitoneal adipose tissue) to 0.112 (for BMI). An assessment of the relationship between the criteria for assessing adipose tissue and lifelong cardiovascular risk showed statistical significance for all criteria with a determination coefficient from 0.122 (for the thickness of preperitoneal adipose tissue) to 0.266 (for BMI). Evaluation of the relationship in linear multivariate regression models of criteria for assessing adipose tissue, systolic blood pressure (SBP), non-HDL cholesterol and lifetime cardiovascular risk showed the statistical significance of all predictors included in the model. Limitations. The study include neither men nor women over 50 and under 19 years. Conclusion. All studied anthropometric and ultrasonographic characteristics of adipose tissue in young women have a comparable effect on the parameters of the lipid spectrum of blood plasma and the calculated lifetime cardiovascular risk, while the significance of their contribution to cardiovascular risk is lower than blood pressure and atherogenic lipid fraction.