NON-PLASMIN-THROMBOLYTICS: NECESSITY, OPPORTUNITIES AND PROSPECTS (review of literature data and own research)

Abstract

State of the problem. Thrombotic complications are a common risk factor for a variety of diseases and are one of the leading causes of death. This leads to a strong interest in finding effective means of prevention and treatment. A characteristic feature of the last decade is the growing interest and numerous attempts to introduce into clinical practice fibrinolytic enzymes that are not functionally related to the hemostasis system. The aim of the work. Investigation of molecular mechanisms that cause the lack of efficiency of native fibrinolysis in relation to fibrin clots with impaired regularity of fibrin structure. Correlation of own achievements in the field of biochemistry and medicine with systematized literary material. The possibilities created by non-plasmin fibrinolytics and the advantages of their use are considered. Discussion and conclusions. The reasons of the complications caused by insufficient efficiency of both own fibrinolytic system, and the entered fibrinolytics are substantiated. It is shown that the leading role in such complications is played by violation of the regularity of the structure of fibrin clots. The mechanisms of action of leading fibrinolytic agents are considered and the expediency of using alternative non-plasmin fibrinolytics is substantiated. The properties and expediency of the use of fibrinolytics based on components of snake venoms and bacterial proteinases as effective means for the breakdown of fibrin with impaired regularity of structure are discussed. Key words: fibrosis, thrombotic therapy, fibrinolytic enzymes, hemostasis system.