Benzodiazepines: Kamo griadeshi?

Abstract

BENZODIAZEPINES: KAMO GRIADESHI? Mykolay Ya. Golovenko A. V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Lyustdorfs’ka doroha Str., 86, Odesa 65080, Ukraine Introduction. Benzodiazepines are among the most prescribed medications in the world because of their demonstrated effectiveness at treating serious physical and mental disorders. The high frequency of clinical use is because of their anxiolytic, anticonvulsant, amnestic, muscle relaxant, and sedative-hypnotic properties. Unfortunately, benzodiazepines also cause unwanted side effects, for example excessive (or unwanted) sedation, tolerance, dependence, and a abuse. The aim – by combining own pharmacological and medical studies together with the systematized literature data to determine the historical circumstances, which facilitated BDZs to lead the all the lists of "the most frequently prescribed" following by oblivion. To set up the future way marks for these compounds. Quo vadis, BDZs? And toward what our path lies? To foresee the possible obstacles and challenges on the thorny way of use of well-known and creating of innovative BDZs derivatives. Materials and methods. When writing the review, searches were undertaken in two representative databases: PubMed and Google Scholar. The search of scientific articles published from 1970 to 2022 was performed. Results and conclusions. The available publication data were systemized and the brief information concerning the BDZs derivatives administration was provided. It was found that in most of the cases throughout the long period, BDZs perceiving still remains negatively biased without substantial scientific background. More and more often the appeals rise to renew the deliberations of problems of the medical use of BDZs in adherence to the exact prescriptions and conceptual stringency in the related comments. The social aspects of benzodiazepines administrations were discussed. The common conclusion was made that benzodiazepines use in the ranges of corresponding medical practice significantly overbalances the possible problems. Considered the possibilities of creating selective innovative medicines as new BDZs derivatives and the conveniences of their use. Keywords: benzodiazepines, indications, side effects, «designer benzodiazepine», improving access.