Many disciplines are facing a “reproducibility crisis”, ushering in much discussion about how to improve research integrity, reproducibility, and transparency. A unified effort across all sectors, levels, and stages of the research ecosystem is needed to coordinate goals and reforms that focus on open and transparent research practices, while promoting a more positive incentive culture for all. In this commentary, we - the Local Network Leads of the UK Reproducibility Network - outline our response to the UK House of Commons Science and Technology Committee’s inquiry on research integrity and reproducibility. We argue that the four areas for effective actions are to coordinate: (1) a positive research culture, (2) a unified stance on improving research quality, (3) common foundations for open and transparent research practice, and (4) the routinisation of this practice. For each of these areas, we outline the role that individuals, institutions, funders, publishers, and Government play in shaping the research ecosystem. Working together, these constituent members must also partner with sectoral and coordinating organisations to produce effective and long-lasting reforms that are fit-for-purpose and future-proof. These efforts will strengthen research quality and create research capable of generating far-reaching applications with a sustained impact on society.