This study investigates the phenomenon of defectiveness in Russian case and number noun paradigms from the perspective of distributional semantics. We made use of word embeddings, high-dimensional vectors trained from large text corpora, and compared the observed paradigms of nouns that are defective in the genitive plural, as suggested by Zaliznjak (1977), with the observed paradigms for non-defective paradigms. When the embeddings of about 20,000 inflected forms were projected onto a two-dimensional space, clusters of case and number within case were found, suggesting global semantic similarity for words with the same inflectional features. Moreover, defective lexemes were characterized by lower semantic transparency, in that inflected forms of the same lexeme are semantically less similar to each other, and their meanings are also more idiosyncratic. Furthermore, compared to non-defective lexemes, inflected forms from defective lexemes are further away from the idealized average case-number meanings, obtained by averaging over the vectors of all inflected forms of the same case-number combination. As a consequence, the semantics of defective forms are predicted less precisely by a simple model of conceptualization that assumes that the meaning of a given Russian inflected form is approximated well by the sum of pertinent embeddings of the lexeme, case, and number within case. We conclude that semantics, at least the kind captured by word embeddings, also contributes to the defectiveness of Russian noun paradigms.