The ability to form and access memories of our experiences involves complex neural mechanisms at both the cellular and systems levels. Animal and human (including lesion and neuroimaging) studies have evidenced a critical role for the hippocampus and connected brain regions in these processes. The current chapter will review the role of the hippocampus in the different stages of long-term memory, namely, encoding, consolidation, and retrieval. Specifically, this chapter will illustrate how the hippocampus, in conjunction with other brain regions, supports these processes, giving rise to our rich experience of remembering.