Affiliation:
1. Henan University of Technology, College of Food Science and Technology, Henan Food Crop Collaborative Innovation Center, No. 100 Lianhua Street, Zhengzhou City, Henan Province, People’s Republic of China 450001
Abstract
Background: Deoxynivalenol (DON) is a type B trichothecene that occurs predominantly in grains such as wheat, maize, and barley and has been implicated in incidents of mycotoxicoses in both humans and farm animals. Objective: In the present study, we chose 60Co
γ-ray irradiation to degrade DON. Methods: First, the degradation effect of irradiation on DON was analyzed. Second, the toxicity analyses of radiolysis products were studied by oral gavage. Results: The results indicated that 60Co γ-ray irradiation had
significant degradation effect on pure DON: when 20 kGy γ-ray irradiation was used for 2 μg/mL DON in acetonitrile–water, the degradation efficiency of DON was 83%, and 2 μg/mL DON in ultra-pure water was completely degraded after 5 kGy γ-ray irradiation. The concentration
of 200 μg/mL DON in ultra-pure water had significant toxicity to mice: decreased body weight gain and feed consumption as well as pathological changes in liver and kidney were observed compared with the control group. Conclusions: No significant toxicity was observed in mice that
were given these degraded solutions treated by γ-ray irradiation, which indicated that the toxicity of radiolysis products in ultra-pure water had significantly decreased after treatment by γ-ray irradiation. Highlights: This research offered some reference to detoxify DON
in cereal grains.
Publisher
Oxford University Press (OUP)
Subject
Pharmacology,Agronomy and Crop Science,Environmental Chemistry,Food Science,Analytical Chemistry
Cited by
11 articles.
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