Simultaneous Determination of Nitrofuran Metabolites and Chloramphenicol in Shrimp with a Single Extraction and LC-MS/MS Analysis

Author:

El-Demerdash Aref1,Song Fenhong2,Reel Robin K1,Hillegas Judy1,Smith Robert E1

Affiliation:

1. U.S. Food and Drug Administration, 11510 W 80th St, Lenexa, KS 66214, USA

2. U.S. Food and Drug Administration, ORA/ORS/MPTSS, Rockville, MD 20857

Abstract

Abstract A method has been developed to quantify the nitrofuran metabolites 3-amino-5-morphorinomethyl-1,3-oxazolidinone, 3-amino-oxazolidinone, 1-aminohydantoin, and semicarbazide, as well as chloramphenicol in shrimp with a single extraction procedure followed by LC-MS/MS analysis. Dynamic selected reaction monitoring with positive and negative ionization mode switching was used. The method LODs were 0.5 ng/g for the nitrofuran metabolites and 0.3 ng/g for chloramphenicol.

Publisher

Oxford University Press (OUP)

Subject

Pharmacology,Agronomy and Crop Science,Environmental Chemistry,Food Science,Analytical Chemistry

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