Effects of Retinal Degeneration and Brain Size upon Spatial Reversal Learning in Mice

Abstract

Mice selected for high brain weight were superior to unselected controls in initial and reversal learning of a spatial discrimination in a water T-maze. Mice selected for low brain weight were superior to controls on initial learning but not on reversals. The presence of retinal degeneration in the low line and in some controls was not an important factor in performance in this maze.