Abstract
Trends in research on affective disorders were reviewed. Studies which described the contribution of neurotransmitters and neuroendocrines to depression, unipolar and bipolar, and manic states were cited. Women more frequently suffer from affective disorders but women's response to different therapies sometimes is more favorable than men's. Age and married status influence sex differences in the incidence of affective disorders. Symptoms of pain and depression intertwine, and response to analgesia may emerge as an index of response to therapy for depression. Trends in pharmacotherapies for affective disorders were reviewed: lithium, tricyclic antidepressants, and MAOI drugs, as well as trends in the employment of ECT and sleep deprivation to relieve symptoms of affective disorders were reviewed.