Shock Sensitization and Fear Potentiation of Auditory Startle Response in Hamsters

Abstract

It is well known that an auditory startle response can be modulated by several processes. In the present study shock sensitization and fear potentiation were examined in 17 hamsters to assess whether response enhancement is similar for another rodent. Immediately after presentation of electrical foot shocks, the auditory startle response increased significantly. This response was also enhanced after fear conditioning in the Experimental group using a light as a conditioned stimulus (CS) and the foot shock as the unconditioned stimulus (US). The auditory startle response remained unchanged in the Control group after nonpaired presentation of CS and US. Significant correlation between enhancement of the auditory startle response in sensitization and fear conditioning was found for the Experimental group. Shock sensitivity and effect of fear on modulation of the auditory startle response in hamsters are similar to those of other rodents. Further, neural mechanisms underlying enhancement of the auditory startle response seem not to be responsible for the deficit of prepulse inhibition in hamsters.