Exploring Body Weight, Voluntary Activity, and Intrinsic Value in Rats

Abstract

Modeling activity-based anorexia, food-deprived rats consistently show that activity increases as weight decreases. This effect was explored in 8 food-deprived, Sprague-Dawley rats as potentially mediated by intrinsic value of activity. Running-wheel activity rates were recorded for free-fed weight, reduction to 90% of free-fed weight, and to 80% of free-fed weight. As expected, activity increased as weight decreased. Further, significant differences appeared in the trends of individual run rates when compared across all trials. These individual trends were expressed as varied rates of running, with extreme high and low run rates prevalent. The rewarding nature of exercise itself might serve to predict these trends in individual rats and reveal potential indicators for the development of activity-based anorexia.