Failure of Peripheral Dopamine β-Hydroxylase Inhibitor to Affect Discriminated Sidman Avoidance Learning in Rats under Long-Term Training

Abstract

5-dimethyldithiocarbamylpicolinic acid (YP-279) is a selective inhibitor of peripheral dopamine β-hydroxylase (DβH). After 72 training days in a discriminated Sidman avoidance situation, rats were administered three dosages (25, 50, and 75 mg/kg) of YP-279. YP-279 treatment produced no observable change in avoidance responses. These results indicate that well-learned coping behavior was not influenced by the inhibition of peripheral DβH.