Effect of Dramamine on the Objective Electrical Vestibulogram

Abstract

The effects of Dramamine and a placebo (Vitamin C) were investigated on subjective responses and on the objective electrical vestibulogram. The latter is a plot of objectively determined absolute thresholds (RLs) against stimulus frequency for a lateral swaying response in standing, blindfolded Ss to sinusoidal electrical stimuli of various frequencies passed between S's mastoid processes. Numbers of subjective responses were not significantly different under the Dramamine and placebo conditions. The only effect on the objective vestibulogram was a rise in the RL at 0.20 cps. The results did not suggest any hypothesis as to the site of action of the drug, but did suggest that its mechanism in preventing the symptoms of motion sickness is very specific.