Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers

Author:

Mondal Susmita12,Roy Debarshi1ORCID,Sarkar Bhattacharya Sayantani1,Jin Ling1,Jung Deokbeom1,Zhang Song3,Kalogera Eleftheria4,Staub Julie1,Wang Yaxian1,Xuyang Wen1,Khurana Ashwani1,Chien Jeremey5ORCID,Telang Sucheta6,Chesney Jason6,Tapolsky Gilles7,Petras Dzeja3,Shridhar Viji1

Affiliation:

1. Department of Experimental Pathology; Mayo Clinic; Rochester MN

2. Department of Microbiology; Sammilani Mahavidyalaya; Kolkata India

3. Division of Cardiovascular disease, Department of Medicine; Mayo Clinic; Rochester MN

4. Division of Gynecologic Surgery, Department of Obstetrics and Gynecology; Mayo Clinic; Rochester MN

5. Division of Molecular Medicine; University of New Mexico School of Medicine; Albuquerque NM

6. Department of Medicine; University of Louisville; Louisville KY

7. Advanced Cancer Therapeutics; Louisville KY

Funder

Mayo Clinic

National Institutes of Health

Publisher

Wiley

Subject

Cancer Research,Oncology

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