Single‐cell genetic analysis of clonal dynamics in colorectal adenomas indicates CDX2 gain as a predictor of recurrence

Author:

Fiedler David1,Heselmeyer‐Haddad Kerstin2,Hirsch Daniela1,Hernandez Leanora S.2,Torres Irianna2,Wangsa Darawalee2,Hu Yue2,Zapata Luis34,Rueschoff Josef5,Belle Sebastian67,Ried Thomas2ORCID,Gaiser Timo1ORCID

Affiliation:

1. Institute of Pathology, University Medical Center MannheimMedical Faculty Mannheim, Heidelberg University Mannheim Germany

2. Genetics Branch, Center for Cancer ResearchNational Cancer Institute, National Institutes of Health Bethesda MD

3. Centre for Evolution and CancerThe Institute of Cancer Research London United Kingdom

4. Genomic and Epigenomic Variation in Disease GroupCentre for Genomic Regulation (CGR), The Barcelona Institute of Science and Technology Barcelona Spain

5. Institute of Pathology Nordhessen Kassel Germany

6. Department of Internal Medicine IIUniversity Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University Mannheim Germany

7. Central Interdisciplinary Endoscopy UnitUniversity Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University Mannheim Germany

Funder

Boehringer Ingelheim Stiftung

Publisher

Wiley

Subject

Cancer Research,Oncology

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