Simultaneous determination of N-benzylpiperazine and 1-(3-trifluoromethylphenyl)piperazine in rat plasma by HPLC-fluorescence detection and its application to monitoring of these drugs

Author:

Wada Mitsuhiro1,Yamahara Kozue1,Ikeda Rie1,Kikura-Hanajiri Ruri2,Kuroda Naotaka1,Nakashima Kenichiro1

Affiliation:

1. Department of Clinical Pharmacy; Graduate School of Biomedical Sciences; Nagasaki University; 1-14 Bunkyo-machi; Nagasaki; 852-8521; Japan

2. National Institute of Health Sciences; 1-18-1 Kamiyoga, Setagaya; Tokyo; 158-8501; Japan

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference28 articles.

1. Pharmacokinetics of ‘party pill’ drug N-benzylpiperazine (BZP) in healthy human participants;Antia;Forensic Science International,2009a

2. In vivo interactions between BZP and TFMPP (party pill drugs);Antia;New Zealand Medical Journal,2009b

3. Acute psychosis following ingestion of ‘Rapture’;Austin;Australasian Psychiatry,2004

4. Effects of ‘Legal X’ piperazine analogs on dopamine and serotonin release in rat brain;Baumann;Annals of the New York Academy of Science,2004

5. N-Substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or ‘Ecstasy’);Baumann;Neuropsychopharmacology,2005

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