Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology

Author:

Bayes‐Genis Antoni123ORCID,Aimo Alberto45,Jhund Pardeep6,Richards Mark7,de Boer Rudolf A.8,Arfsten Henrike9,Fabiani Iacopo5,Lupón Josep1,Anker Stefan D.10,González Arantxa311,Castiglione Vincenzo4,Metra Marco12,Mueller Christian13,Núñez Julio314,Rossignol Patrick15,Barison Andrea5,Butler Javed16,Teerlink John17,Filippatos Gerasimos18,Ponikowski Piotr19,Vergaro Giuseppe45,Zannad Faiez20,Seferovic Petar2122,Rosano Giuseppe23,Coats Andrew J.S.24,Emdin Michele45,Januzzi James L.25

Affiliation:

1. Institut del Cor Hospital Universitari Germans Trias i Pujol Barcelona Spain

2. Department of Medicine Universitat Autònoma de Barcelona Barcelona Spain

3. CIBERCV, Carlos III Institute of Health Madrid Spain

4. Scuola Superiore Sant'Anna Pisa Italy

5. Cardiology Division Fondazione Toscana Gabriele Monasterio Pisa Italy

6. Institute of Cardiovascular & Medical Sciences University of Glasgow Glasgow UK

7. University of Otago Dunedin New Zealand

8. Department of Cardiology University Medical Centre Groningen Groningen The Netherlands

9. Clinical Division of Cardiology, Department of Internal Medicine II Medical University of Vienna Vienna Austria

10. Department of Cardiology (CVK), and Berlin Institute of Health Center for Regenerative Therapy (BCRT), German Center for Cardiovascular Research (DZHK) partner site Berlin Charité Universitätsmedizin Berlin Germany

11. Program of Cardiovascular Diseases CIMA Universidad de Navarra and IdiSNA, Navarra Institute for Health Research Pamplona Spain

12. Cardiology Department, ASST Spedali Civili; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia Brescia Italy

13. Department of Cardiology University Hospital Basel Switzerland

14. Hospital Clínico Universitario de Valencia, INCLIVA Universidad de Valencia Valencia Spain

15. Academic Hospital (CHU) Nancy France

16. Department of Medicine University of Mississippi Medical Center Jackson MS USA

17. Heart Failure and of the Echocardiography Laboratory San Francisco Veterans Affairs Medical Center San Francisco CA USA

18. HF Unit Attikon University Hospital Athens Greece

19. Centre for Heart Diseases University Hospital Wroclaw Poland

20. Université de Lorraine, Centre d'Investigations Cliniques‐Plurithématique 1433, and Inserm U1116 CHRU Nancy, F‐CRIN INI‐CRCT Nancy France

21. Department of Cardiology University Clinical Center of Serbia Belgrade Serbia

22. Serbian Academy of Sciences and Arts Belgrade Serbia

23. IRCCS San Raffaele Rome Italy

24. University of Warwick Coventry UK

25. Massachusetts General Hospital and Baim Institute for Clinical Research Boston MA USA

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

Reference78 articles.

1. Gaining Efficiency in Clinical Trials With Cardiac Biomarkers

2. Statista. Success rate of novel cardiovascular disease drugs by development phase in the United States in 2008‐2019.https://www.statista.com/statistics/1186648/us‐clinical‐development‐success‐rate‐novel‐cardiovascular‐drugs(accessed 13 September 2022).

3. Biotechnology Innovation Organization.Clinical Development Success Rates 2006–2015. June 2016.https://www.bio.org/sites/default/files/legacy/bioorg/docs/Clinical%20Development%20Success%20Rates%202006‐2015%20‐%20BIO %20Biomedtracker %20Amplion%202016.pdf(accessed 13 September 2022).

4. Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework

5. Biomarkers for the diagnosis and management of heart failure

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