Challenges in the Development of Intravenous Neurokinin‐1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose‐Finding, Phase 1 Study of Intravenous Fosnetupitant-Reference-Cited by-同舟云学术

Challenges in the Development of Intravenous Neurokinin‐1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose‐Finding, Phase 1 Study of Intravenous Fosnetupitant

Published:2022-10-20 Issue:12 Volume:11 Page:1405-1418
ISSN:2160-763X
Container-title:Clinical Pharmacology in Drug Development
language:en
Short-container-title:Clinical Pharm in Drug Dev

Author:

Tyler Timothy¹,Schultz Armin²,Venturini Alessio³,Giuliano Claudio³,Bernareggi Alberto³,Spezia Riccardo³,Voisin Daniel³,Stella Valentino⁴

Affiliation:

1. Comprehensive Cancer Center Desert Regional Medical Center Palm Springs California USA

2. CRS Clinical Research Services Mannheim GmbH Mannheim Germany

3. Helsinn Healthcare SA Lugano/Pazzallo Switzerland

4. Pharmaceutical Chemistry The University of Kansas Lawrence Kansas USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.1183

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2. Efficacy and Cost: Avoiding Undertreatment of Chemotherapy-Induced Nausea and Vomiting

3. Adverse Drug Events Related to Dosage Forms and Delivery Systems

4. Polysorbates 20 and 80 Used in the Formulation of Protein Biotherapeutics: Structure and Degradation Pathways

5. Tolerability of Fosaprepitant and Bioequivalency to Aprepitant in Healthy Subjects

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1. 2023 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting;ESMO Open;2024-02

2. A study on the efficacy and safety of aprepitant injection in preventing and treating nausea and vomiting induced by platinum‐based chemotherapy in lung cancer;Precision Medical Sciences;2024-01-11

3. Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates;Chemical Society Reviews;2024

4. 2023 updated MASCC/ESMO consensus recommendations: prevention of nausea and vomiting following high-emetic-risk antineoplastic agents;Supportive Care in Cancer;2023-12-21