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The generation of stable, high MAb expressing CHO cell lines based on the artificial chromosome expression (ACE) technology

  • Published:2009-10-15 Issue:3 Volume:104 Page:540-553
  • ISSN:0006-3592
  • Container-title:Biotechnology and Bioengineering
  • language:en
  • Short-container-title:Biotechnol. Bioeng.

Author:

Kennard Malcolm L.,Goosney Danika L.,Monteith Diane,Zhang Lin,Moffat Mark,Fischer David,Mott John

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference10 articles.

1. Novel generation of human satellite DNA-based artificial chromosomes in mammalian cells;Csonka;J Cell Sci,2000

2. Satellite DNA-based artificial chromosomes for use in gene therapy;Hadlaczky;Curr Opin Mol Ther,2001

3. Generating stable, high-expressing cell lines for recombinant protein manufacture;Kennard;BioPharm Int,2007

4. Dynamic, structural, and regulatory aspects of lambda site-specific recombination;Landy;Annu Rev Biochem,1989

5. A mammalian artificial chromosome engineering system (ACE System) applicable to biopharmaceutical protein production, transgenesis and gene-based cell therapy;Lindenbaum;Nucleic Acids Res,2004

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