Interactions between antiseizure medications and foods and drinks: A systematic review

Author:

Asadi‐Pooya Ali A.12ORCID,Johannessen Landmark Cecilie34ORCID,Mirzaei Damabi Nafiseh1,Fazelian Khatereh1

Affiliation:

1. Epilepsy Research Center, Shiraz University of Medical Sciences Shiraz Iran

2. Jefferson Comprehensive Epilepsy Centre, Department of Neurology Thomas Jefferson University Philadelphia Pennsylvania USA

3. Department of Pharmacy, Faculty of Health Sciences Oslo Metropolitan University Oslo Norway

4. The National Centre for Epilepsy, Member of the ERN EPiCare, and Dept. of Pharmacology Oslo University Hospital Oslo Norway

Abstract

AbstractAntiseizure medications (ASMs) constitute the principal of treatment for patients with epilepsy, where long‐term treatment is usually necessary. The purpose of this systematic review is to provide practical and useful information regarding various aspects of the interactions between ASMs and foods and drinks. MEDLINE and ScienceDirect, from the inception to July 15, 2023, were searched for related publications. In both electronic databases, the following search strategy was applied, and the following keywords were used (in title/abstract): “food OR drink” AND “antiepileptic OR antiseizure.” The primary search yielded 738 studies. After implementing our inclusion and exclusion criteria, we could identify 19 studies on the issue of interest for our endeavor. Four studies were identified in the recheck process and not by the primary search. All studies provided low level of evidence. Interactions between foods and ASMs are a common phenomenon. Many factors may play a role for such an interaction to come to play; these include drug properties, administration route, and administration schedule, among others. Drugs‐foods (‐drinks) interactions may change the drug exposure or plasma levels of drugs (e.g., grapefruit juice increases carbamazepine concentrations and the bioavailability of cannabidiol is increased 4–5 folds with concomitant intake of fat‐rich food); this may require dosage adjustments. Interactions between ASMs and foods and drinks may be important. This should be taken seriously into consideration when consulting patients and their caregivers about ASMs. Future well‐designed investigations should explore the specific interactions between foods (and drinks) and ASMs to clarify whether they are clinically important.Plain Language SummaryInteractions between antiseizure medications and foods and drinks may be important. This should be taken into consideration in patients with epilepsy.

Publisher

Wiley

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