1. Institute of Clinical Medicine, Internal Medicine University of Eastern Finland Kuopio Finland
2. Institute of Biomedicine, Bioinformatics Center University of Eastern Finland Kuopio Finland
3. NMR Metabolomics Laboratory, School of Pharmacy University of Eastern Finland Kuopio Finland
4. Computational Medicine, Faculty of Medicine University of Oulu and Biocenter Oulu Oulu Finland
5. Center for Medicine and Clinical Research Kuopio University Hospital Kuopio FIN‐70029 KYS Finland