The impact of multifocal perineural invasion in predicting survival in patients with oral squamous cell carcinoma: A multicenter investigation-Reference-Cited by-同舟云学术

The impact of multifocal perineural invasion in predicting survival in patients with oral squamous cell carcinoma: A multicenter investigation

Published:2023-08-10 Issue:10 Volume:45 Page:2605-2612
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Hasmat Shaheen¹²^ORCID,Heller Gillian²,Cook Lachlan³⁴,Gupta Ruta¹²⁵,Clark Jonathan R.¹²⁶,Ooi Eng H.³⁴,Low Tsu‐Hui (Hubert)¹²⁷

Affiliation:

1. Central Clinical School, Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia

2. Sydney Head and Neck Cancer Institute Chris O'Brien Lifehouse Sydney New South Wales Australia

3. Department of Otolaryngology – Head and Neck Surgery Flinders Medical Centre and Royal Adelaide Hospital Adelaide South Australia Australia

4. Department of Surgery, College of Medicine and Public Health Flinders University Bedford Park South Australia Australia

5. Department of Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital, NSW Health Pathology Sydney New South Wales Australia

6. Royal Prince Alfred Institute of Academic Surgery Sydney Local Health District Sydney New South Wales Australia

7. Department of Otolaryngology – Head & Neck Surgery, Faculty of Medicine and Health Sciences Macquarie University Sydney New South Wales Australia

Abstract

AbstractBackgroundPerineural invasion (PNI) in oral squamous cell carcinoma (OSCC) does not contribute to the current American Joint Committee on Cancer 8th edition (AJCC8) staging manual. This study seeks to validate the effect of multifocal PNI in a large cohort of patients.MethodsPatients undergoing primary surgical treatment of OSCC with curative intent between 1995 and 2022 was retrieved from two Australian head and neck databases. PNI was categorized as a single focus or multiple foci. Study end points included disease‐specific survival (DSS) and overall survival (OS).ResultsComplete data for survival analysis was available in 993 patients. Multifocal PNI was associated with a 61% increased risk of death due to OSCC (HR 1.61, 95% CI 1.11–2.33, p = 0.014) and a 32% increased risk of death from any cause (HR 1.32, 95% CI 1.01–1.73, p = 0.045).ConclusionsMultifocal PNI is a significant predictor of survival in OSCC.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27485

Reference25 articles.

1. The incidence of squamous cell carcinoma of the oral tongue is rising in young non-smoking women: An international multi-institutional analysis

2. Primary Tumor Staging for Oral Cancer and a Proposed Modification Incorporating Depth of Invasion

3. Tumor thickness versus depth of invasion – Analysis of the 8th edition American Joint Committee on Cancer Staging for oral cancer

4. Prognostic implications of the 8th edition American Joint Committee on Cancer (AJCC) staging system in oral cavity squamous cell carcinoma

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Prognostic and predictive biomarkers in head and neck cancer: something old, something new, something borrowed, something blue and a sixpence in your shoe;Pathology;2023-12