Prediction of human blood-to-plasma drug concentration ratio

Author:

Uchimura Takahide,Kato Motohiro,Saito Tomohisa,Kinoshita Haruki

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference25 articles.

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3. Hepatic clearance of drugs. I. Theoretical considerations of a ‘well-stirred’ model and a ‘parallel tube’ model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance;Pang;J Pharmacokinet Biopharm,1977

4. A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations;Roberts;J Pharmacokinet Biopharm,1986

5. Human clearance prediction: shifting the paradigm;Lavé;Expert Opin Drug Metab Toxicol,2009

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