Atorvastatin induces mitochondrial dysfunction and cell apoptosis in HepG2 cells via inhibition of the Nrf2 pathway
Author:
Affiliation:
1. Academy of Military Medical Sciences Beijing People's Republic of China
2. PLA Center for Disease Control and Prevention Beijing People's Republic of China
Funder
National Natural Science Foundation of China
Publisher
Wiley
Subject
Toxicology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jat.3825
Reference50 articles.
1. Population-Based in Vitro Hazard and Concentration–Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study
2. Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2
3. Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump
4. Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2
5. Efficacy and Safety of a New HMG-CoA Reductase Inhibitor, Atorvastatin, in Patients With Hypertriglyceridemia
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