Synthesis of Chromeno[2,3‐b]quinoline derivatives via ZnCl2‐Mediated three‐component reaction of 2‐Aminochromenones, benzaldehydes and Cyclohexane‐1,3‐dione

Abstract

AbstractA novel ZnCl2‐promoted three‐component reaction strategy for the synthesis of hexahydrochromeno[2,3‐b]quinoline derivatives via the Aldol condensation/Michael addition/cycloaddition/dehydration cascade reaction of 2‐amino‐4H‐chromen‐4‐ones, aromatic aldehydes, and cyclohexane‐1,3‐dione was investigated. This procedure is environmentally friendly, highly efficient, and has a broad scope. The structures of the products obtained were determined based on x‐ray diffraction studies.