Functional self-assembled peptide scaffold inhibits tumor necrosis factor-alpha-induced inflammation and apoptosis in nucleus pulposus cells by suppressing nuclear factor-κB signaling

Author:

Li Xiaochuan12,Cheng Shi1,Wu Yaohong13,Ying Jingwei1,Wang Chaofeng1,Wen Tianyong1,Bai Xuedong1,Ji Wei1,Wang Deli1,Ruan Dike1

Affiliation:

1. Department of Orthopedic Surgery; Navy General Hospital; Beijing People's Republic of China

2. Department of Orthopedic Surgery; The People's Hospital of Gaozhou; Guangdong People's Republic of China

3. Department of Spinal Surgery; The Affiliated Ganzhou Hospital of Nanchang University; Ganzhou Jiangxi People's Republic of China

Funder

National Natural Science Foundation of China

www.nsfc.gov.cn

Publisher

Wiley

Subject

Metals and Alloys,Biomedical Engineering,Biomaterials,Ceramics and Composites

Reference42 articles.

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3. BMSC paracrine activity attenuates interleukin-1beta-induced inflammation and apoptosis in rat AF cells via inhibiting relative NF-kappaB signaling and the mitochondrial pathway;Hu;Am J Trans Res,2017

4. TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc;Wang;J Biol Chem,2011

5. Aberrant Low Expression of A20 in Tumor Necrosis Factor-alpha-stimulated SLE Monocytes Mediates Sustained NF-kappaB Inflammatory Response;Shi;Immunol Invest,2015

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